Valencia maintained their perfect start to the season with a comfortable 4-2 away win over Real Valladolid.
Elsewhere, Deportivo La Coruna, Sporting Gijon and Tenerife all secured home wins while Villarreal were held.
Valencia have moved joint-top of the Liga table following an emphatic 4-2 away win over Real Valladolid.
David Silva gave Los Che the lead after 10 minutes, but Nauzet Aleman equalised on the half hour mark.
Crucially David Villa restored Valencia's lead within minutes and they moved 3-1 in front before half-time courtesy of Juan Mata.
Valladolid had to keep things tight after the interval so Villa's second effectively killed off the tie, however, Manucho did muster a consolation.
Deportivo bounced back from their defeat on the opening weekend of the season with a 1-0, hard-fought win over Malaga.
Filipe's terrific goal with just eight minutes left in the contest proved the decisive moment of the match.
Sporting Gijon's season is up and running after they got the better of Almeria with a 1-0 success.
The goal came early on with Diego Castro's strike after just six minutes giving the home side the points.
Real Mallorca battled back from a goal down to secure a 1-1 draw at Villarreal.
Ex-Manchester United striker Giuseppe Rossi opened the scoring in the second half, but Borja Valero secured a share of the spoils.
The draw means new coach Ernesto Valverde is still looking for his first win two games into the new campaign.
Tenerife secured their first points of the new Liga season with a 2-1 win over nine-man Osasuna.
After an uneventful first half the visitors were up against it when two quick-fire bookings saw Eraso Nacho dismissed.
Nino then put the home side ahead, but veteran hit-man Walter Pandiani shocked the home side with an equaliser.
Ricardo Leon restored Tenerife's lead permanently before Osasuna lost their second man of the game when Javad Nekounam was dismissed.
Sunday's late kick-off saw Athletic Bilbao claim a 1-0 win at Xerez. David Prieto's first half own goal settled the contest.
The home side's hope of salvaging a late point were dashed when Jaszs Mendoza was given his marching orders.
