The Russian favorite sprayed shots to all parts of the court at Roland Garros, giving her opponent few chances on Day 2 of the tournament.
“I was just playing point by point, game by game, and it ended up like this,” said Safina, who with Marat Safin forms the only brother-sister combination to have held the No. 1 ranking.
Keothavong had a couple of chances against Safina, but she wasted two break points in the third game of the first set, and led 40-0 in the fourth game of the second but couldn’t hold on.
“When that’s happening to you all you want to do is get on the scoreboard, but I wasn’t able to do that,” said Keothavong, who saved four match points before Safina hit a forehand winner down the line. “It just kept getting harder and harder.”
Victoria Azarenka and Ana Ivanovic won 6-0, 6-0 at the French Open last year, and Serena Williams did it in 2003.
Williams, a seven-time Grand Slam champion, survived a sudden second-set slump to beat Bethanie Mattek-Sands 6-1, 4-6, 6-2. She won the match’s first five games, while Mattek-Sands asked for a medical timeout during the first set so a trainer could look at her right wrist.
“I’m definitely a third-set player,” Williams said. “Once I get to the third set ... I feel a new level coming.”
Williams has never won the French Open, but she did reach the final in 2002 when she lost to little sister Serena. Overall, Williams holds a 36-12 record at Roland Garros, giving her the most wins of any player in the women’s draw at the tournament.
Sharapova played with a bandage on her right shoulder, and she struggled in the first set before beating Anastasiya Yakimova of Belarus 3-6, 6-1, 6-2.
The unseeded Russian was broken three times in the first set, but she opened the second with four straight wins before being broken once again. Before the start of the next game, Yakimova called for a trainer to work on her lower back.
“I started pretty lousy,” said Sharapova, playing a Grand Slam match for the first time since last year’s Wimbledon. “I was just a little sloppy. But I totally changed it around, and I started playing a lot better and more aggressive.”
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