Andres Iniesta has been ruled out of Spain's World Cup qualifiers against Turkey.
The midfielder limped out of Barcelona's 6-0 victory over Malaga on Sunday with a thigh complaint and is set to be sidelined for around 15 days.
Yaya Toure also suffered a problem and is expected to be out for the same amount of time.
Barca boss Pep Guardiola confirmed: "Andres and Yaya picked up injuries and will be out for about 15 days."
Barcelona's next game is against Real Valladolid in the Primera Liga on 5th April, while they will face Bayern Munich in the UEFA Champions League three days later.
Both players will hope to be back in action by then but news of Iniesta's injury will come as a blow to Spain.
The Euro 2008 winners face Turkey at home next Saturday before tackling the same opponents away the following Wednesday.