Villarreal captain Marcos Senna will miss the second leg of his team's UEFA Champions League quarter-final clash with Arsenal.
The influential midfielder suffered a hamstring injury during Villarreal's 2-0 home defeat by Malaga in La Liga on Saturday evening.
Senna picked up the problem 10 minutes from time and has been ruled out of Wednesday's trip to Emirates Stadium.
The length of absence has not yet been confirmed by Villarreal, but he is definitely not available to Villarreal coach Manuel Pellegrini for the game in North London.
The Spain international had scored a stunning opener in the first leg at home before Emmanuel Adebayor's acrobatic equaliser for the Gunners.
Pellegrini has several injury worries for the return encounter, with Santi Cazorla also not at his disposal, while Cani and Matias Fernandez are doubtful.
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