Ferrero, who was unseeded at the clay-court event, broke Serra six times to win for the first time since the Madrid Masters in October 2003. That year, Ferrero won his only Grand Slam title at the French Open and lost in the U.S. Open final to Andy Roddick.
Ferrero now owns 12 career titles.
Serra was chasing a third title after last winning in Adelaide, Australia, in January 2006.
Rapids outlast Galaxy in Open Cup play-in match
Red Bulls feeling pressure to perform
Ferrero beats Serra to win Casablanca final
Rapids outlast Galaxy in Open Cup play-in match
Red Bulls feeling pressure to perform
Ferrero beats Serra to win Casablanca final