Nadal, the four-time defending champ who had a first-round bye, has beaten Chela in four of five matches, including all three on clay. Nadal's lone defeat to Chela came five years ago on hard courts in Cincinnati.
"Chela is a good clay-court player. I have to play good tennis if I want to have good chances to win,'' Nadal said. "(I need to) try to play aggressive without a lot of mistakes.''
Andreas Seppi of Italy advanced with a 6-2, 6-0 win over Jurgen Melzer of Austria and will play second-ranked Roger Federer.
Oscar Hernandez of Spain defeated Julien Benneteau of France 6-4, 6-4. He will meet No. 3 Novak Djokovic of Serbia.
Federer accepts wild card for Monte Carlo Masters
Crew, Rapids meet at early crossroads
Federer accepts wild card for Monte Carlo Masters
Week 3 marked by hats, cards, surprises
